Lecture: Professor David Spring Department of Chemistry, University of Cambridge

Title: Enriching Chemical Space to Drug Undruggable Targets

2017.09.08 | Susan Hjort Skyum

Date Fri 22 Sep
Time 11:15 12:15
Location Aarhus Universitet, iNANO Auditorium (1593-012), Gustav Wieds Vej 14, 8000 Aarhus C

Abstract: The pharmaceutical industry is an enormously successful business sector. However, the current challenges facing the industry are unprecedented. Foremost among these challenges are the industry's diminishing revenue forecasts due to the decreasing number of new chemical entity (NCE) approvals. A high attrition rate of clinical candidates (ca. 93-96%) is prevalent throughout the industry. Pharma's recent dramatic restructuring is largely due to this high attrition rate. My talk aims to highlight some of the underlying factors of this. Namely, (1) the relative lack of structural diversity and (2) the relative lack of targets exploited in drug discovery. The talk will include recent research within my laboratory aimed at addressing these issues, specifically macrocycle libraries and stapled peptide methodology.

Department of Chemistry, Staff, Public / media, Department of Molecular Biology and Genetics, iNANO