Troels Skrydstrup was born in Frederiksberg (Denmark) in 1961. He grew up in Canada in Montréal , Quebec and Iroquois, Ontario, Canada. He received a BSc(Eng.) degree from Queen’s University, Kingston, Canada (1983) and his MSc and PhD degrees from the Technical University of Denmark (1985 and 1988) under the supervision of Prof. Anders Kjær. After several post-doctoral periods at the Institute de Chimie des Substances Naturelles, Gif-sur-Yvette (1988–1989 with Prof. G. Ourisson, 1990–1992 with Dr. D. Grierson) and at the Carlsberg Laboratories (1989–1990 with Prof. K. Bock), Troels Skrydstrup was employed as Chargé de Recherche (CR1) both at the Université d’Orléans and Université Paris XI (1992–1997).
In 1997, he became Associate Professor at the Department of Chemistry, Aarhus University, and was promoted full Professor of Organic Chemistry in 2002. Troels Skrydstrup was Head of Department in the period 2001–2004 and 2010.
In 2001, he obtained the Danish Doctor of Science degree. Troels Skrydstrup was elected as a fellow of the Royal Danish Academy of Sciences in 2008, and member of the Danish Academy of Natural Sciences in 2010. He has also served in the committee of the Danish Council for Independent Research in the field of Natural Sciences from 2009–2010. Troels Skrydstrup has over 205 publications, two patents and two pending patent applications, an H-index of 31.
Troels Skrydstrup was in 2014 awarded with a Center of Excellence "Carbon Dioxide Activation Centre (CADIAC)" by the Danich National Research Foundation.