Department of Chemistry

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 Department of Chemistry Research Research areas and groups Organic chemistry Bioorganic Chemistry Publications

Publications

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Lindkvist, T. T., Sillesen, C., Klinkby, N., Jensen, H. H., Andersen, L. H. & Nielsen, S. B. (2025). Photophysics of a Methylated GFP Chromophore Anion in Vacuo. Journal of Physical Chemistry A, 129(19), 4245–4251. https://doi.org/10.1021/acs.jpca.5c02039
Cordua, N., Steffensen, S. R., Mascherpa, A. G., Christensen, L. G. & Jensen, H. H. (2025). Purification-Free Preparation of Trifluoroacetimidoyl Chlorides and Their Use in Catalytic Chemical Glycosylation. Organic Letters, 27(7), 1602-1607. https://doi.org/10.1021/acs.orglett.4c04525
Kumar, S., Nikelshparg, E., Pilátová, J., Paul, A., Kumar, V., Koren, G., Beck, R., Jensen, H. H. & Segal, D. (2025). Self-Assembly of Accumulated Sphingolipids into Cytotoxic Fibrils in Globoid Cell Leukodystrophy and Their Inhibition by Small Molecules In Vitro. ACS Nano, 19(27), 25180-25203. https://doi.org/10.1021/acsnano.5c05498
Juul-Madsen, L., Cordua, N., Greve, R. D., Pedersen, K., Trinderup, H. H., Petersen, E. & Jensen, H. H. (2025). The Stereochemical Outcome of Galactosylations Is Influenced by Both the Position and Electron-Withdrawing Power of Distal Acyl Protecting Groups. The Journal of Organic Chemistry, 90(20), 6662-6671. https://doi.org/10.1021/acs.joc.4c02956
Pedersen, K., Christensen, L. G. & Jensen, H. H. (2023). Formation of β-Configured Thioglycosides of D-Glucosamine and D-Galactosamine and Synthesis of Protected Human Milk Oligosaccharides. Journal of Organic Chemistry, 88(17), 12531–12541. https://doi.org/10.1021/acs.joc.3c01267
Greve, R. D. & Jensen, H. H. (2023). Lewis Acid Promoted Deprotection of Benzylidene Acetals and p-Methoxybenzyl Ethers with Mercaptoacid Acid as Scavenger. Organic Letters, 25(20), 3628-3632. https://doi.org/10.1021/acs.orglett.3c00958
Trinderup, H. H., Sandgaard, T. L. P., Juul-Madsen, L. & Jensen, H. H. (2022). Anomeric Thioglycosides Give Different Anomeric Product Distributions under NIS/TfOH Activation. Journal of Organic Chemistry, 87(6), 4154-4167. https://doi.org/10.1021/acs.joc.1c03001
Jensen, D. L., Trinderup, H. H., Skovbo, F. & Jensen, H. H. (2022). Solvent free, catalytic and diastereoselective preparation of aryl and alkyl thioglycosides as key components for oligosaccharide synthesis. Organic and Biomolecular Chemistry, 20(24), 4915-4925. https://doi.org/10.1039/d2ob00939k
Trinderup, H. H., Juul-Madsen, L., Press, L., Madsen, M. & Jensen, H. H. (2022). α-Selective Glucosylation Can Be Achieved with 6- O- para-Nitrobenzoyl Protection. Journal of Organic Chemistry, 87(21), 13763-13789. https://doi.org/10.1021/acs.joc.2c01475
Trinderup, H. H., Andersen, S. M., Heuckendorff, M. & Jensen, H. H. (2021). How do Various Reaction Parameters Influence Anomeric Selectivity in Chemical Glycosylation with Thioglycosides and NIS/TfOH Activation? European Journal of Organic Chemistry, 2021(22), 3251-3259. https://doi.org/10.1002/ejoc.202100260
Viuff, A., Salamone, S., McLoughlin, J., Deane, J. E. & Jensen, H. H. (2021). The Bicyclic Form of galacto-Noeurostegine Is a Potent Inhibitor of β-Galactocerebrosidase. ACS Medicinal Chemistry Letters, 12(1), 56-59. https://doi.org/10.1021/acsmedchemlett.0c00377
Kjær, C., Hansson, R. F., Hedberg, C., Jensen, F., Jensen, H. H. & Nielsen, S. B. (2020). Gas-phase action and fluorescence spectroscopy of mass-selected fluorescein monoanions and two derivatives. Physical Chemistry Chemical Physics, 22(17), 9210-9215. https://doi.org/10.1039/d0cp00453g
Marqvorsen, M. H. S., Brinkø, A. & Jensen, H. H. (2020). On the electron withdrawing nature of ethers in glycosylation chemistry. Carbohydrate Research, 487, Article 107886. https://doi.org/10.1016/j.carres.2019.107886
Hedberg, C., Jessen, K. S., Hansson, R. F., Heuckendorff, M. & Jensen, H. H. (2020). Palladium-Catalyzed C-S Bond Formation as a Tool for Latent-Active Glycosylation. Organic Letters, 22(18), 7068-7072. https://doi.org/10.1021/acs.orglett.0c02090
Brinkø, A., Risinger, C., Lambert, A., Blixt, O., Grandjean, C. & Jensen, H. H. (2019). Combining Click Reactions for the One-Pot Synthesis of Modular Biomolecule Mimetics. Organic Letters, 21(18), 7544-7548. https://doi.org/10.1021/acs.orglett.9b02811
Underlin, E. N. & Jensen, H. H. (2019). Synthesis of nortropane alkaloid calystegine B2 from methyl α-D-xylopyranoside. Carbohydrate Research, 472, 122-126. https://doi.org/10.1016/j.carres.2018.12.002
Heuckendorff, M. & Jensen, H. H. (2018). DIDMH in combination with triflic acid - A new promoter system for thioglycoside glycosyl donors. Carbohydrate Research, 455, 86-91. https://doi.org/10.1016/j.carres.2017.11.012
Heuckendorff, M., Poulsen, L. T., Hedberg, C. & Jensen, H. H. (2018). Dissection of the effects that govern thioglucoside and thiomannoside reactivity. Organic and Biomolecular Chemistry, 16(13), 2277-2288. https://doi.org/10.1039/c7ob02968c
Knudsen, I. M. B., Hedberg, C., Ladefoged, L. K., Ide, D., Brinkø, A., Eikeland, E. Z., Kato, A. & Jensen, H. H. (2018). Divergent synthesis of new α-glucosidase inhibitors obtained through a vinyl Grignard-mediated carbocyclisation. Organic & Biomolecular Chemistry, 16(34), 6250-6261. https://doi.org/10.1039/c8ob01433g
Poulsen, L. T., Heuckendorff, M. & Jensen, H. H. (2018). Effect of 2- O-Benzoyl para-Substituents on Glycosylation Rates. ACS Omega, 3(6), 7117-7123. https://doi.org/10.1021/acsomega.8b00880
Poulsen, L. T., Heuckendorff, M. & Jensen, H. H. (2018). On the generality of the superarmament of glycosyl donors. Organic and Biomolecular Chemistry, 16(13), 2269-2276. https://doi.org/10.1039/c7ob02966g
Hedberg, C., Estrup, M., Eikeland, E. Z. & Jensen, H. H. (2018). Vinyl Grignard-Mediated Stereoselective Carbocyclization of Lactone Acetals. Journal of Organic Chemistry, 83(4), 2154-2165. https://doi.org/10.1021/acs.joc.7b03079
Heuckendorff, M. & Jensen, H. H. (2017). Removal of some common glycosylation by-products during reaction work-up. Carbohydrate Research, 439, 50-56. https://doi.org/10.1016/j.carres.2016.12.007
Marqvorsen, M. H. S., Pedersen, M. J., Rasmussen, M. R., Kristensen, S. K., Dahl-Lassen, R. & Jensen, H. H. (2017). Why Is Direct Glycosylation with N-Acetylglucosamine Donors Such a Poor Reaction and What Can Be Done about It? Journal of Organic Chemistry, 82(1), 143-156. https://doi.org/10.1021/acs.joc.6b02305
Kristensen, S. K., Salamone, S., Rasmussen, M. R., Marqvorsen, M. H. S. & Jensen, H. H. (2016). Glycosyl ortho-Methoxybenzoates: Catalytically Activated Glycosyl Donors with an Easily Removable and Recyclable Leaving Group. European Journal of Organic Chemistry, 2016(32), 5365-5376. https://doi.org/10.1002/ejoc.201600747

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Revised 17.04.2023
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Henrik Helligsø Jensen