G-quadruplexes can be found in different places in the genome. In telomeres, they have been reported to hinder telomere elongation by telomerase, which is an important process in cancer. G-quadruplexes with the human telomere sequence have large conformation diversity, which also makes them interesting complex nanostructures. We use single molecule FRET microscopy to investigate this diversity in different environments and DNA protein interactions.
A. C. Krüger, M. K. Raarup, M. Muhlig Nielsen, M. Kristensen, F. Besenbacher, J. Kjems, V. Birkedal, 2010, "Interaction of hnRNP A1 with telomere DNA G-quadruplex structures studied at the single molecule level ", Euro. Biophys. J. 39, p. 1343-1350.
